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Which blood type is the rarest?
Question
#45451. Asked by Gold-Star.
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romeomikegolf
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In order of rarety the groups are:
O: Rh (D) Pos: 38%, Rh (D) Neg: 7%, Total: 45%.
A: Rh (D) Pos: 36%, Rh (D) Neg: 7%, Total: 43%.
B: Rh (D) Pos: 8%, Rh (D) Neg: 1%, Total: 9%.
AB: Rh (D) Pos: 2%, Rh (D) Neg: 1%, Total: 3%.
Although the figures show Bneg and ABneg as the same, ABneg is found in less than 1% of the population, and Bneg in just over 1%.
These percentages apply to the UK.
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McGruff
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The Bombay blood group is a rare group except in parts of India where a frequency of 1 in 7,600 has been observed. A high level of consanguinity has been observed among the parents of the Bombay phenotype. Individuals with the Bombay phenotype fail to express ANY A, B, or H antigen on their red cells or other tissues.
http://www.bh.rmit.edu.au/mls/subjects/abo/resources/frequency4.htm
Can a Caucasian have Bombay blood?
The classic Bombay phenotype has only been reported in those of Indian descent. It is quite rare with an incidence of 1 in 250,000. The bombay phenotype is characterized by mutations in fucosyltransferase. Fucosyltransferase is an enzyme that adds sugars to molecules exposed on the red blood cell surface. These sugars are used to determine the ABO blood type. Therefore a person with Bombay has the phenotype of O blood even though genetically they might have a different blood type. Since these are independent those with Bombay blood type are not necessarily one blood type (they could be any). There are similar phenomena to Bombay phenotype. There is a para-Bombay phenotype in which the fucosyltransferase levels are greatly reduced. This occurs in Chinese individuals with a frequency of 1 in 8,000. Also the Bombay phenotype is one of many elements of Rambam-Hasharom which is a genetic syndrome also characterized by mental retardation. IT is thought the genetic lesion here is quite large.
http://www.madsci.org/posts/archives/jul2000/964701803.Ge.r.html
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