Has it been proven conclusively that schizophrenia is hereditary? If so, can it be passed from parent to child or does it skip generations?

McGruff

15. Is schizophrenia hereditary? People who have a relative with schizophrenia have a greater risk of developing the disorder than the general population. For example, if you have an identical twin with schizophrenia, your chance of having schizophrenia is 50% in contrast to the 1% chance for the public at large. Adoption studies have shown that biological relatives have an increased risk for schizophrenia whereas adoptive relatives have no increased risk. Such studies clearly point to the contribution of a genetic component in the development of schizophrenia. Nongenetic factors can also influence the development of schizophrenia, as evidenced by the fact that, even in people with identical genes (i.e., monozygotic twins), only in about 50% of the cases are both twins ill. http://www.mhsource.com/schizophrenia/schizfaq.html#15 Jul 11 05, 1:23 PM

lanfranco

Several sites, including this one, indicate that the degree of heritability of schizophrenia has not been fully established. If you have a schizophrenic relative (parent, grandparent, or sibling), your chances of developing the disease are greater. On the other hand, one identical twin may have the disease while the other does not. Clearly, factors other than the genetic may play a role, including pre-partum neurobiological problems, though exactly how they might do so isn't yet entirely clear: http://en.wikipedia.org/wiki/Schizophrenia Jul 11 05, 1:26 PM

barker111

In the world of psychiatry almost nothing has been 'proven conclusively'. Jul 11 05, 3:27 PM

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