There's a switch on the bottom of wireless mice. You could try just turning that off (saves on battery usage as well) until you next need to use the puter, rather than rebooting (not that rebooting occasionally isn't a good idea, as postie has said, since doing so should clear your cache and fix other issues on its own).
Somebody should tell us, right at the start of our lives, that we are dying. Then we might live life to the limit, every minute of every day. Do it! I say. Whatever you want to do, do it now! There are only so many tomorrows.
Pope Paul VI