* What is the true identity of Shredder?
* What turtle can only face Hun, and what turtle can only face Dr. Stockman, in that order?
* In the last Dojo stage before "Stage 6: Justice", the turtles must fight Leonardo, assuming he's Shredder. Who does Leonardo face?
* What does Shredder send Hun and the Foot Clan out to collect?
* Which is not one of the Mystic Ninjas?
* What is the name of April's antique shop?
* How many Giant Mouser Robots, in total, must the turtles face in Story Mode?
* Which turtle must you be to face Casey Jones?
* In the opening sequence of Story Mode, Splinter is trying to get the turtles to extinguish a flame. Which unsuccessful turtle does Splinter call "too clumsy"?
* What turtle can work computer consoles to bring down security lasers, force fields, etc.?
* In "Episode 1-1: The Cavern", how do you get the antique?
* On the stages where you have to collect gold and silver coins, how many points must you get in order to collect the antique?
* Where is the first place that the Transmat Chamber teleports the turtles to?
* What is the true identity of Fugitoid?
* Who is the leader of the Utroms that the turtles become friends with?
* Who lost their memory but gained it back, realizing Shredder was behind their family's death?
* How many different one-on-one battles must you wage against Ultimate Ninja?
* Who is responsible for Leatherhead's death?
* Who is NOT one of the groups vying for control of New York City?
* In the original arcade game that is unlocked after appraising the antique from "Episode 9-1: Mean Streets" in 2nd Time Around, how many bosses from the original arcade game are not included in this one?