1. Which of these leaders of great empires was not killed or severely mutilated by smallpox? Isabella I (Spain) Ramesses V (Egypt) Huayna Capac (Inca) Mary II (England, Queen of Scots)

2. Who was Edward Jenner? The first victim of the smallpox vaccine The diplomat who brought variolation to England The man who claimed the vaccine turned victims into cows The inventor of the smallpox vaccine

3. You would need to be vaccinated against smallpox if you traveled to which nation? Somalia U.S. citizens are already vaccinated Vaccination is unneccessary Mexico

4. What is the basis for the current fear of bioterrorists using smallpox as a weapon? Recent smallpox outbreaks in Afghanistan Soviet-era smallpox weapons in the wrong hands Mutation of a live vaccine strain into a disease strain Al-Qaida operatives in the CDC

5. The World Health Organization Smallpox Eradication Program (WHOSEC) destroyed the last laboratory smallpox (Variola major) sample, eliminating Variola major from the Earth, in 1980. True False

6. The remote location and frigid arctic air protected the Inuit from the smallpox epidemics that devastated many native communities in North America. True False

7. What was considered the best cure for people infected with smallpox? None of these Herpes-specific antivirals Antibiotics Picornaviral-specific antivirals

8. What is the 'ring vaccination'? The pus-filled lesion left by vaccination with live vaccinia The technique of vaccinating a region surrounding an epidemic The selection of vaccination sites concentrated at lymph nodes The technique of vaccinating contacts of smallpox victims

9. The symptom of smallpox infection that is associated with the ONSET of the contagious stage is what? Incubation (no symptoms) Fever (prodrome) Rash Pustule bursts

10. Cotton Mather suggested that variolation (a pre-vaccine technique) be used to protect the population during the 1721 Smallpox epidemic in Boston. Like many advocates of variolation, what was he called by his critics? A traitor A murderer A saint A troglodyte