What song has reached the Billboard Hot 100 the most times counting by different artists?

As best as I can tell, after searching the charts and various lists with songs that have appeared by multiple artists, it is most likely to be the 1961 Ben E. King song "Stand By Me". The song has been recorded over 500 times, and several of these made the chart. In all, seven versions of "Stand By Me" have charted.

1961: Ben E. King (peaked at No. 4)
1967: Spyder Turner (peaked at No. 12)
1970: The Ruffin Brothers (peaked at No. 61)
1975: John Lennon (peaked at No. 20)
1980: Mickey Gilley (peaked at No. 22)
1985: Maurice White (peaked at No. 50)
1998: 4 the Cause (peaked at No. 82)

Excellent answer! Almost could add in, "Stand By Me" by Prince Royce. The bachata version went top ten on four Billboard Latin charts but didn't break the Billboard Hot 100.